Mediator Release Test “MRT”
Testing offered to NWHS clients only
Why MRT® is the Most Complete Blood Test for Food Sensitivities Despite all of the clinical and immunologic complexities associated with food sensitivities, the single common component of all diet-induced inflammatory reactions is proinflammatory and proalgesic mediator release from white cells. It’s the release of cytokines, histamine, leukotrienes, prostaglandins, etc., from neutrophils, monocytes, eosinophils and lymphocytes that lead to all the negative clinical effects a food sensitivity sufferer endures. This is true under all of the numerous immunologic circumstances and clinical circumstances associated with food sensitivities. Because of the vast array of potential mediators and reacting cells, measuring volumetric changes in all circulating white cells after antigen challenge is the most logical, direct, comprehensive and functional measure of food sensitivity reactions. It simply makes the most sense.
Research on MRT® confirms this. Studies with the University of Miami and research presented at major medical conferences show that MRT® is able to distinguish between symptomatic and asymptomatic populations, that MRT® correlates with inflammation and symptoms, that diets based on MRT® show significant symptom reduction, and that MRT® has excellent real-world reproducibility.
Conversely, a large body of research has shown that elevated mechanisms in food sensitivity, such as food-specific IgG or immune complexes, do not reliably correlate with inflammation or symptoms.
Mediator release is the key event that leads to every negative effect people suffer from. What matters clinically is that mediator release, and thus an inflammatory response has occurred – not that a potential mechanism is elevated.
This is the clinical value of MRT®. MRT® is a functional measurement of diet-induced sensitivity pathways. MRT® simplifies a highly complex reaction and translates that into the most useable clinical information you can get – quantifying the inflammatory response to foods and food-chemicals.
Not only does MRT® give insight into inflammation provoking foods and food-chemicals, but more importantly MRT® identifies the BEST foods you should be eating.
Simply put, MRT® gives you information you can’t get any other way, and that information directly translates into targeted therapy that matters.
MRT® is the foundation of fully addressing food sensitivities and achieving the maximum outcomes in the shortest period of time.
Understanding Food Sensitivity
There are 3 categories of diet-induced inflammatory reactions: Food Allergy, Food-Induced Autoimmune Disease, and Food Sensitivities. Of the 3, food sensitivities are the most prevalent.
Food and food-chemical sensitivities are highly complex non-allergic (non-IgE), non-celiac inflammatory reactions. They follow multiple inflammatory pathways and may be governed by either innate or adaptive immune mechanisms. They’re one of the most important sources of inflammation and symptoms across a wide range of chronic inflammatory conditions. They are also one of the most clinically challenging.
Due to their inherent clinical and immunologic complexities, as well as a lack of general knowledge within conventional medicine of their role as a source of inflammation in IBS, migraine, fibromyalgia, arthritis, GERD, obesity, metabolic syndrome, ADD/ADHD, autism, etc., food and food-chemical sensitivities remain one of the most under addressed areas of conventional medicine.
Food and food-chemical sensitivities have clinical characteristics that make it very challenging to identify trigger foods. For example, symptom manifestation may be delayed by many hours after ingestion; reactions may be dose dependent; because of a breakdown of oral tolerance mechanisms, there are often many reactive foods and food-chemicals; even so-called anti-inflammatory foods, such as salmon, parsley, turmeric, ginger, blueberry, and any “healthy” food can be reactive.
Medical Conditions Where Food Sensitivities Can Play a Primary or Secondary Role
- Irritable Bowel Syndrome
- Functional Diarrhea
- Crohn’s Disease
- Ulcerative Colitis
- Microscopic Colitis
- Lymphocytic Colitis
- Cyclic Vomiting Syndrome
- Autism Spectrum Disorders
- Restless Leg Syndrome
- Inflammatory Arthritis
- Atopic Dermatitis
- Chronic Fatigue Syndrome
- Interstitial Cystitis
- Polycystic Ovary Syndrome
Recent research into adverse reactions to gluten has uncovered a new form of diet-induced inflammation termed “non-celiac gluten sensitivity” (or GS). Gluten sensitivity is 6-8 times more prevalent than celiac disease, can provoke a wide range of clinical symptoms, and has been proven to activate the innate immune system, a branch of the immune system that has been almost completely neglected for years by researchers as a source of diet-induced inflammation and symptoms. But gluten is just one potential piece of the puzzle. As stated previously, any food can trigger an inflammatory response, even so-called anti-inflammatory foods. The key is to know which specific foods and food-chemicals are triggering reactions in each specific patient. That’s the beginning of the best way to design an eating plan that will produce the maximum clinical benefit.
Common Feature of Food Sensitivities
The single common feature of all diet-induced inflammatory reactions is that they ultimately cause mediator release (cytokines, leukotrienes, prostaglandins, etc.) from various white blood cells (neutrophils, monocytes, eosinophils, lymphocytes). This is true whether reactions are immediate or delayed, whether dose dependent or not, whether governed by the innate or adaptive immune systems, whether cell-mediated or humorally-mediated, and whether inflammation remains at a sub-clinical level or becomes clinically symptom-provoking. All food-induced inflammatory reactions involve mediator release, which is the single most important event leading to all the negative effects people suffer from, including symptom generation. Information from: https://nowleap.com/the-patented-mediator-release-test-mrt/
For the MRT food testing, please read the directions in the box carefully and fill out all requested information. For payment, please leave blank as you already purchased this test through NWHS. Please go to www.nowleap.com/draw-locator to find a lab near you who draws blood specifically for MRT testing. You can walk in or set up an appointment ahead of time. You may want to call to verify that they provide phlebotomy services before you go, as sometimes policies are change, and we are not notified. As directed in the instructions, plan on getting your blood drawn 12:30pm or later. You do NOT need to be fasting for this test.
GI Map Stool Test
Testing offered to NWHS clients only
The Gastrointestinal Microbial Assay Plus or “GI-MAP test”, is an at home testing kit and is one of the newest advances to the list of the most sought-after medical tests today. The chief goal of this test is to use one stool sample to examine your overall digestive function which is a key factor in our overall health as many diseases and medical conditions today originate in the gut.
Who is the G.I Map Stool Test for?
The G.I. Map stool test can be performed at any age and be used for those suffering from an array of health issues and medical conditions. Examples include: digestion problems like constipation, bloating, diarrhea, gas, acid reflux, irritable bowel disease or “IBS”, heart disease, thyroid issues, hormone imbalances and autoimmune diseases.
The G.I Map Test measures:
- Pancreatic and immune function
- Occult blood
- Secretory IgA
- Anti-gliadin IgA
- Fat absorption
The benefits of the G.I Map Test
What’s good about the G.I. Map Stool Test is that it is something that you can do at home and has a higher accuracy rate compared to conventional stool testing due to its innovative technology. In addition, this test gives a big picture view of what is occurring in the gut microbiome while also assessing other health markers making it possible to also analyze inflammation and immunity. With the help of this at home test, your stool will be used in determining if there are certain pathogenic organisms within your body that might cause you to suffer from illnesses linked to digestive conditions, hormonal imbalances, autoimmune problems, and most chronic conditions can be influenced by your gut bacteria.
Please review all instructions carefully before collecting your at home stool sample. For payment, please leave blank as you already purchased this test through NWHS.
Please stop taking all digestive supplements like general probiotics, enzymes, hydrochloric acid, antimicrobial and anti-parasitic agents, and gut healing formulas for three days before the test.
Stop spore-forming and soil-based probiotics two weeks prior to specimen collection. If antibiotics have been taken, wait two weeks before doing the test.
Ingest 70-100 grams of fat each day for three days prior to collection. This would be 2-3 tablespoons of added fat or oil to each meal in the day. For example, a salad with 1/2 an avocado, a small handful of nuts, and a salad dressing with at least 1 Tbsp olive oil in it would be 2-3 tablespoons of added fat.
If you want to know if you have a reaction to gluten, be sure to have at least three servings of bread, pasta or other gluten-containing grains during the week before collecting your stool specimen.
All prescription medications, other than antimicrobial formulas, anti-parasitic agents, and antibiotics, should be continued during the collection process.
Do not collect your sample while menstruating as blood is a contaminant that will void the test. Be sure to write your name and date of birth on all vials.
Please plan the timing so that you mail it to the lab on a Monday or Tuesday. This ensures the specimen is viable when it reaches the lab.
If you need to take something in order to defecate, you can drink senna tea.
You will find a prepaid FedEx sticker inside the kit to mail to mail the specimen to the lab. Simply drop it at any FedEx pick up facility.
Please see instructions inside testing kit for more information.